CT,clinical and pathological features of primary pulmonary lymphoepithelioma-like carcinoma / 实用放射学杂志

Objective To investigate CT,clinical and pathological features of primary pulmonary lymphoepithelioma-like carcinoma (LELC). Methods The clinical,CT and pathological data of 22 patients with pulmonary LELC confirmed by pathology were analyzed retrospectively, including 8 males and 1 4 females whose ages were from 1 8 to 88 years old.Results Among 22 cases,1 2 patients were found by physical examination,2 patients had cough and sputum,7 patients had cough hemoptysis and 1 patient was found by re-examination after breast cancer surgery.On CT,all cases manifested single mass in the lung,and the longer diameters ranged from 1.5 cm to 1 1 cm,in which there were central type tumors in 8 cases and peripheral type tumors in 14 cases.Nineteen masses showed homogeneous density in non-enhanced scan,and the cavity,irregular calcification and small patchy necrosis were seen in each 1 case.After contrast-media injected,masses were mild-moderately or evidently enhanced in 7 cases and 1 5 cases respectively.Eighteen cases had well defined border and unclear border in 4 cases.Vascular encasement were found in 6 central type tumors,8 tumors squeezed peripheral vascular and 8 cases had clear demarcation between tumors and vascular.Nineteen tumors were surgically removed,in which 7 cases appeared metastasis of lymph node.Histopathology showed that the tumor cells had large volumes,unclear boundaries,large nuclei,growing in syncytial nest-like patches.There were abundant lymphocyte and plasma cell infiltration in tumor’s mesenchyma.EBER were done in 1 6 cases and the results were all positive.Conclusion CT feature of pulmonary LELC manifestes that the masses are mostly single,large size, homogeneous density,clearly boundary,shallow lobulated and significantly enhancement.Vascular encasement is the feature of central pulmonary LELC,and peripheral LELC is more likely to occur in the sub-pleural region.Final diagnosis should be combined with clinical and pathological diagnosis.

Clinical efficacy of radiotherapy for stage ⅠE Primary ocular adnexal mucosa associated lymphoid tissue lymphoma / 中华放射肿瘤学杂志

Objective To evaluate the dose response and prognosis of patients with stage ⅠE primary ocular adnexal mucosa associated lymphoid tissue lymphoma (POAml) treated with radiotherapy.Methods Clinical date of 93 patients (117 eyes) with stage ⅠE POAml treated from November 2003 to July 2015 were retrospectively analyzed.The dose response was evaluated by observing the ocular changes in exophthalmos.The survival rate was calculated by using the Kaplan-Meier survival analysis.The log-rank test and univariate analysis were used for prognostic analysis.Results For patients treated with a dose of ≥ 27 Gy,the response rate of exophthalmos was 69.0％(29/42).The median response dose was 7.2 Gy (5.4-19.8 Gy).For all patients,the local control rate was 100％.The 5-and 10-year overall survival (OS) rates were 92％ and 82％.The 5-and 10-year cause-specific survival (CSS) rates were equally 98％.The 5-and 10-year progression-free survival (PFS) rate were 90％ and 88％.The univariate prognostic analysis demonstrated that the International Prognostic Index (IPI) score and age were the prognostic factors of PFS rate (both P=0.04).Conclusions POAml is sensitive to radiation therapy.Radiotherapy alone can yield excellent local control and long-term survival in POAml patients.A prescription dosage of 18 Gy dose can obtain favorable clinical efficacy.

Screening of lncRNAs in female non-smoking lung cancer patients based on TCGA data / 临床检验杂志

Objective@#To screen the differentially expressed long non-coding RNAs(lncRNAs) by analyzing the related gene sequencing data of female non-smoking lung cancer patients in the database of The Cancer Genome Atlas (TCGA). @*Methods@#The gene expression data and the corresponding clinical information of female non-smoking lung cancer patients were downloaded from the TCGA database. Then, the data were processed, integrated and analyzed with the R software package, and the differentially expressed genes were screened out. The prognosis was analyzed by the Survival package. @*Results@#A total of 354 differentially expressed lncRNAs associated with female non-smoking lung cancer were obtained, of which 45 were down-regulated and 309 were up-regulated in tumor tissues. The prognosis analysis showed that the expression level of LINC01863 was positively correlated with the prognosis of female non-smoking lung cancer patients (P＜0.05), and that the expression levels of LINC02487, LINC01419 and DSCAM-AS1 were negatively correlated with the prognosis of female non-smoking lung cancer patients (P＜0.05). @*Conclusion@#The re-analysis on the high-throughput sequencing data in TCGA database obtains a large number of lncRNAs related to the development of female non-smoking lung cancer, which provides the potential new targets for the diagnosis and prognosis assessment of female non-smoking lung cancer.

Effect of rhynchophylline on the mRNA expression of excitatory amino acid transporter 2 and NMDA receptor 2B after oxygen-glucose deprivation in cultured rat hippocampal astrocytes / 国际脑血管病杂志

Objective To investigate the effect of rhynchophylline on mRNA expression of excitatory amino acid transporter 2 (EAAT2 ) and N-methyl-D-aspartic acid receptor 2B (NR2B) after astrocyte oxygen-glucose deprivation. Methods The subcultured third generation astrocytes from the hippocampus were inoculated into 6-well plates, and they were divided into blank control group, hypoxia-ischemia group,low-dose rhynchophylline group (0. 02 mg/ml) and high-dose rhynchophylline group (0. 2 mg/ml) after the cells were attached to the wall and grew out protrusion. The total RNAs in each group were extracted.Real-time fluorescence quantitative polymerase chain reaction was used to detect the expression levels of EAAT2 and NR2B mRNA in astrocytes of each group. Results Compared with the blank control group, the expression levels of NR2B and EAAT2 mRNA in astrocytes of the ischemia-hypoxia group were significantly higher (all P < 0. 05 ). The expression levels of NR2B and EAAT2 mRNA in the low-dose rhynchophylline group were lower than those in ischemia-hypoxia group, but there was no significant difference. The expression levels of NR2B and EAAT2 mRNA in the high-dose rhynchophylline group were significantly lower than the ischemia-hypoxia group and the low-dose rhynchophylline group (all P < 0. 05).Conclusion The expression of EAAT2 and NR2B mRNA in astrocytes of hippocampus cultured in vitro was significantly increased after ischemia and hypoxia, and rhynchophylline intervention could significantly reduce its expression in a concentration dependent manner.

Efficacy of saxagliptin combined with acarbose in the treatment of newly diagnosed type 2 diabetes mellitus / 中国生化药物杂志

Objective To investigate the clinical effect and analysis of Shah Glenn Dean combined with acarbose in the treatment of newly diagnosed elderly patients with type 2 diabetes mellitus.Methods 60 cases of newly diagnosed elderly patients treated in our hospital during the period from January 2015 to January 2017 in patients with type 2 diabetes mellitus is selected as the object of this study, they were randomly divided into control group and study group, 30 cases in each group.The control group was treated with acarbose treatment, the study group was treated with Shah Glenn Dean combined acarbose treatment, treatment time was 3months, glycosylated hemoglobin, after two groups of patients were in different treatment of hypoglycemia were observed and compared the rate of change, body mass index and blood glucose level changes.Results The patients in the control group, the incidence of hypoglycemia was 23.33%, patients in the study group, the incidence of hypoglycemia was 6.67%, patients in the study group,the incidence of hypoglycemia was significantly lower than that of control group, the difference was statistically significant between the groups(P <0.05); glycosylated hemoglobin levels in the study group were significantly lower than that of the control group of two patients, the difference was statistically significant between the groups(P <0.05); the total cost of the patients in the treatment group compared with the control group had no significant difference, the difference was not statistically significant.Conclusion Significant clinical therapeutic effect of saxagliptin combined with acarbose in the treatment of newly diagnosed elderly patients with type 2 diabetes, can make the patient's blood glucose levels were significantly lower,with high security, the incidence of hypoglycemia was significantly reduced, but also can reduce the weight of patients, the total cost in the course of treatment did not increase that will not cause economic burden on patients, it is worthy of clinical application.

Monitoring and analysis of perinatal defects in Lishui city in last decade / 中华全科医师杂志

Objective To analyze the dynamic changes of perinatal defects in Lishui city from 2005 to 2014.Methods According to hospital-based data,87 294 fetuses and infants aged from 28 weeks of gestation to 7 days after birth were monitored for birth defects in Lishui city from 2005 to 2014.Results Among 87 294 perinatal infants,birth defects were found in 1 914 cases with a incidence of birth defects of 219.3/ten thousand,which was on the rise year by year except 2009.The incidence of birth defects was 235.1/ten thousand (737/31 352) in urban areas,which was significantly higher than that in rural areas (210.4/ten thousand,1 177/55 942) (x2 =5.705,P ＜ 0.05).The incidence of birth defects of boys and girls was 221.1/ten thousand (1 005/45 453) and 212.8/ten thousand (890/41 822),respectively (x2 =0.707,P ＞ 0.05).Among 1 914 cases of defects,657 were detected prenatally and 1 257 case were detected within 7 days after birth.Congenital heart disease was the most common birth defect,followed by polydactyly,cleft lip,microtia and syndactyly.Birth defect accounted for 32.74％ (278/849) of all perinatal deaths and the ratio was on the rise since 2010.Conclusion There is an upward trend in incidence of birth defects in Lishui city in the last decade;the incidence of birth defects in urban areas is significantly higher than that in rural areas;the incidence of congenital heart disease is high,and birth defects are the main cause of perinatal death.

Analysis of the influence factors of elderly patients with acute pulmonary thromboembolism and observation of prognosis / 中国基层医药

Objective To explore the related factors of senile acute pulmonary thromboembolism(PTE) patients,and to observe the prognosis and analyze the strategy of control and prevention to reduce the incidence. Methods 50 elderly patients with acute PTE were selected,related factors were analyzed by using the retrospective investigation,and the prevention and control were administrated.Results The mainly disease occurred of the elderly patients with acute PTE were combined with chronic diseases 42% (21 /50),with lower extremity DVT 26.00%(13 /50)and with recent trauma,fracture and operation 20%(10 /50).Elderly patients with acute PTE who were ≥70 years of age and lying in bed the time≥1 month,were 58%(29 /50)and 62%(31 /50),which were higher than those of the other age <70 years old and lying in bed time <1 month of patients,the difference was statistically signifi-cant(χ2 =9.26,9.80,all P <0.05).Conclusion The related risk factors for elderly patients with acute PTE mainly correlate with age,lying in bed time,chronic diseases,patients with lower extremity DVT and recent trauma,fracture, operation,the variety of factors and overlap each other.Mastering the variety factors of PTE in the nursing process,and taking effective measures to prevent and control the factorscan reduce or avoid the occurrence of acute PTE,and im-prove the prognosis of the patients.

Research of Project Management Working Mode of National Drug Reference Standards / 中国药师

To explore the establishment of a scientific and innovative working mode of the national drug reference standards. Methods:Project management was adopted. Results and Conclusion: The project management mode can effectively ar-range the work of the national drug reference standards including raw material collection, research, review, subpackage, package and so on, which exhibits guiding significance for the development direction and improving products supplement.

The identification of the Cryptosporidium ubiquitum in pre-weaned Ovines from Aba Tibetan and Qiang autonomous prefecture in China / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>Cryptosporidium spp. are prevalent globally and sheep are an important zoonotic reservoir. Little data regarding the rates of Cryptosporidium infections in ovines in China are available. This study assessed the prevalence of Cryptosporidium spp. in pre-weaned ovines from Aba Tibetan and Qiang Autonomous Prefecture in the Sichuan province of China.</p><p><b>METHODS</b>A total of 213 fecal samples were collected from pre-weaned ovines and were examined microscopically (following modified acid fast staining). In addition, 18S rRNA genetic sequences were amplified from fecal samples by nested PCR and phylogenetically analyzed.</p><p><b>RESULTS</b>The prevalence of Cryptosporidium in the collected samples was at 14.6% (31/213) and four isolates identified by PCR belonged to the Cryptosporidium cervine genotype (Cryptosporidium ubiquitum) demonstrating that this species was the primary sheep species found in sheep in China.</p><p><b>CONCLUSION</b>The present study suggested that the high incidence of Cryptosporidium in sheep poses a significant public health threat and that surveillance practices must be established to prevent zoonotic disease of humans.</p>

Hospital Infection Management Surveillance Network System:Development and Application / 中华医院感染学杂志

OBJECTIVE To improve the surveillance and control of hospital infection.METHODS A series of management surveillance network information system for hospital infection were established by using SQL Server 2000 as database and Delphi 7.0 as program tool.The system included hospital infection case surveillance subsystem,antibiotic rational usage subsystem and the interface program of hospital information subsystem.RESULTS The hospital surveillance network connected the hospital infection department with the medical laboratory department and inpatient department,so the hospital infection data could be shared by all departments of hospital.CONCLUSIONS The system can improve work efficiency of hospital infection surveillance.

Imaging diagnosis of osteoid osteoma / 中华放射学杂志

Objective To analyze the X -ray, CT, and MR imaging findings in osteoid osteoma. Methods Forty-eight cases of osteoid osteoma proved by surgical pathology were collected, including 33 males and 15 females. Among the 48 cases, all patients had plane films, 32 were imaged with CT scanning, 10 with MR imaging, and 8 with all three techniques. The imaging findings of osteoid osteoma and the ability of X-ray, CT, and MRI in demonstrating the nidus and the surrounding reaction were analyzed. Results The imaging manifestations of osteoid osteoma revealed a circular or oval nidus with different bone sclerosis around the nidus. The diameters ranged from 0.4 cm to 1.7 cm, with the average of 9.7 cm. There were also soft tissue and bone morrow edema around the nidus or distinct effusion of joint on MR imaging in all 10 cases. Among 48 cases, only 37 cases showed nidus on plane film. All 32 cases with CT scanning showed nidus. The display ratios of nidus were 77% for X-ray and 100% for CT, respectively. 10 cases with MR imaging could be diagnosed correctly. But the nidus could be affirmed in only 8 cases, and the nidus was affirmed by comparing with plane film or CT in the other 2 cases. Conclusion Nidus is the key in diagnosing the osteoid osteoma correctly. Plane film is still an important checking method for osteoid osteoma. CT scan is the best method to demonstrate the nidus. MRI can demonstrate the soft tissue and bone morrow edema around the nidus sensitively, but probably lead to an incorrect diagnosis. Combining with X-ray or CT, MRI can make an accurate diagnosis.

Study of standardized A/B ultrasonography for diagnosis of orbital vascular lesions / 中华超声影像学杂志

Objective To study the application of standardized A/B ultrasonography for the orbital vascular lesions. Methods Standardized A/B ultrasonography was performed on orbital vascular lesions of 145 cases. Results The orbital vascular lesions included the cavernous hemangiomas in 79 cases, venous hemangiomas 19 cases, lymphangiomas 15 cases, infantile hemangiomas 5 cases, varix 12 cases and carotid-cavernous sinus fistula 15 cases. The positive rate of standardized A/B scans was 98.6 %, false negative 1.4 %.Conclusions Standardized A/B ultrasonography can make accurate diagnosis for orbital vascular lesions. B-mode ultrasonography mainly shows the shape, location and the relation to normal orbital structure, but A-mode ultrasonography is more accurate in internal reflectivity of lesions, and sound attenuation and quantitative. Combined B-mode and A-mode ultrasonography is more effective for diagnosis of orbital vascular lesions.

Application of Joint Computer Radiography System and High kV Radiography Technique in Diagnosis of Cardiac Disease / 医疗卫生装备

Objective To investigate the application of computer radiography system in combination with high kV radiography technique to diagnose cardiac disease.Methods 30 patients with cardiac disease were taken chest photographs,which chest photographs by CR system and high kV radiography technique were compared with these by common high kV radiography.Results The good rate of air tube occupied is 98% in therapy group,but the rate is only 70% in common group.The discrepant comparison is significant differences.Conclusion It is more significant that CR system in combination with high kV radiography technique than common photograph to diagnose cardiac disease.

The Etiological Diagnosis of Enlarged Superior Ophthalmic Vein with Ultrasonography and Computed Tomography / 第二军医大学学报

B-ultrasonography and/or CT scannings of 84 cases of enlarged superior ophthalmic vein (SOV) were analysed morphologically and etiologically. Carotid-cavernous fistula, ophthalmic Graves disease, Tolosa-Hunt syndrome, orbital vascular deformity, inflammation at the apex of the orbit, orbital pseudo tumor, intraorbital hematoma and thrombosis of the SOV might induce enlargement of SOV. Associated with other Findings of intraorbital tissues revealed by CT and B-ultrasonography, the etiological diagnosis of the enlarged SOV could be made. The dynamic findings of the SOV rendered by B-ultrasonography and Doppler ultrasonic play an important role in the diagnosis of carotid-cavernous fistula.